Dr. David Scott serves as Chief Executive Officer of American Friends of Cancer Research (AFCR), where he provides leadership and oversight of the organization. He also serves as Director of Cancer Grand Challenges, leading the strategic development and delivery of this global initiative. David brings more than 20 years of experience in research funding and management and has held senior leadership positions within Cancer Research UK’s Research and Innovation Directorate, including Director of Discovery Research.

Sebastien Laye serves as Chief Development Officer of American Friends of Cancer Research (AFCR), where he leads global funding and partnership development in support of Cancer Grand Challenges. He works closely with Cancer Research UK and other partners to advance the initiative’s strategic goals. Sebastien brings more than 19 years of experience in development and external affairs, with expertise spanning fundraising, communications, and government relations.

David Machon serves as Managing Director of American Friends of Cancer Research (AFCR), where he leads organizational operations, financial management, governance, and strategic planning in support of the Cancer Grand Challenges initiative. David brings extensive experience in nonprofit leadership, operations, finance, and organizational development, with a focus on building effective and sustainable organizations.